Entry 4
Probiotic science page
Uses mannose-specific gut adhesion to reduce IBS symptoms and improve iron status in deficient athletes, with RCT support.
Overview
299v (DSM 9843) was isolated from the lining of a healthy human gut \[7]. Probi AB (Lund, Sweden) developed it. It is now part of the DSM-Firmenich portfolio. 299v has been studied mostly for irritable bowel syndrome (IBS) and for gut effects related to exercise \[1\]\[2].
Mechanism
A systematic scoping review found strain-specific effects of L. plantarum strains, including 299v. These effects are on gut barrier function and on tuning the immune system [1]. 299v sticks to the cells lining the gut using mannose-specific adhesins. It survives stomach acid and bile at levels the body actually produces [7].
Health Benefits
A strain-specific systematic review with meta-analysis (pools results from multiple trials) found 299v helps IBS symptoms (SR/MA) [2]. An RCT found that supplements with 299v changed kidney, muscle, and gut injury biomarkers during running (RCT) [3]. An RCT in female iron-deficient athletes found that 299v improved iron status and physical performance [8] (RCT). Evidence level: RCT for IBS and exercise-related outcomes.
Biology
Originally named Lactobacillus plantarum. It was reclassified as Lactiplantibacillus plantarum in 2020 [4]. It is Gram-positive. It grows with or without oxygen. It does not form spores. It is a rod. It produces lactic acid plus other byproducts. It was isolated from the lining of the human gut.
Bibliography
Chatsirisakul O, Leenabanchong N, Siripaopradit Y, et al. (2025). Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review. Nutrients. 17(7). PMID: 40218922
Maslennikov R, Gosteeva E, Ananeva V, et al. (2026). Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. J Clin Med. 15(3):1152. PMID: 41682832
Hansson E, Skinner B, Falcone T, et al. (2026). Effects of race distance and probiotics intervention on kidney, muscle, and gut injury and inflammation biomarker responses during running. J Int Soc Sports Nutr. 23(1):2651356. PMID: 41981959
Zheng J, Wittouck S, Salvetti E, et al. (2020). A taxonomic note on the genus Lactobacillus... Int J Syst Evol Microbiol. 70(4):2782-2858. PMID: 32293557
Nordstrom EA, Teixeira C, Montelius C, et al. (2021). "Lactiplantibacillus plantarum 299v (LP299V): three decades of research." Benef Microbes. 12(4):339-350. PMID: 34365915
Axling U, Onning G, Combs MA, et al. (2020). "The Effect of Lactobacillus plantarum 299v on Iron Status and Physical Performance in Female Iron-Deficient Athletes: A Randomized Controlled Trial." Nutrients. 12(5):1252. PMID: 32365981
Available Products
299v is the active ingredient in Probi Digestis (Probi AB) and in GoodBelly (NextFoods). It is also in DSM-Firmenich formulations. These come as capsules, fermented oat drinks, and fruit beverages. Deposited as DSM 9843.